منابع مشابه
Embolic stroke in aged rats.
BACKGROUND AND PURPOSE Although stroke is a disorder associated with aging, experimental studies of stroke are conducted in young adult (2-4-month-old) animals (rat life span, 27-29 months). To determine whether histopathologic changes caused by cerebral infarction would be altered in aged animals, we produced embolic cerebral infarction in 17 aged (23-24-month-old) and 16 young (2-4-month-old)...
متن کاملLongitudinal magnetic resonance imaging of sildenafil treatment of embolic stroke in aged rats.
BACKGROUND AND PURPOSE Sildenafil provides restorative therapeutic benefits in the treatment of experimental stroke. The majority of experimental studies on treatment of stroke have been performed in young animals; however, stroke is primarily a disease of the aged. Thus, using MRI, we evaluated the effects of sildenafil treatment of embolic stroke in aged animals. METHODS Aged male Wistar ra...
متن کاملLongitudinal Magnetic Resonance Imaging of Aged Rats with Sildenafil Treatment after Embolic Stroke
Introduction Advanced age is an important risk factor and a predictor of poor outcome after treatment in stroke patients. Aged rats subjected to stroke had a higher mortality rate and worse neurological deficits than young rats, and pharmacological effects after treatment of stroke in young rats may not necessarily be translated to older rats. Clinical trials for neuroprotective therapy for str...
متن کاملVitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats
Objective(s) Previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke- dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of a-TCT and rosiglitazone (RGZ)...
متن کاملFunctional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor.
BACKGROUND AND PURPOSE Advanced age is associated with a decrease in brain plasticity compared with the young adult. Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor promotes brain plasticity and improves functional outcome after stroke in the young animal. Here, we test the hypothesis that sildenafil provides restorative therapeutic benefit to the aged animal. METHODS Male Wistar rats...
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ژورنال
عنوان ژورنال: Stroke
سال: 1991
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.22.12.1582